Sensitivity of Viscoelastic Tests to Platelet Function

Laboratory tests of platelet function.

Assessment of neonatal platelet function using a viscoelastic technique.

The Sonoclot, a simple viscoelastometer, measures changes in the viscoelastic properties of plasma as it is recalcified. Platelet rich plasma (PRP) and platelet poor plasma (PPP) each have characteristic Sonoclot tracings. This technique was applied to evaluate the coagulability and platelet function, specifically, in PRP prepared from 53 normal term newborn cord bloods and whole blood from 17 ...

Platelet function tests and resistance to antiplatelet therapy.

The clinical efficacy of antiplatelet therapy (aspirin, P2Y12 and glycoprotein IIb/IIIa receptor antagonists) to prevent occlusive arterial events in patients with atherothrombotic disease is well established. Despite the proven benefits of antiplatelet therapy, many patients continue to experience arterial events. Many factors may influence the response of platelets to antiplatelet therapy and...

Platelet function tests in thrombotic cerebrovascular disorders.

A variety of platelet function tests were performed in patients with four forms of obstructive cerebrovascular disease (CVD); transient ischemic attacks (TIA), reversible ischemic neurological deficit (RIND), cerebral infarct, and cerebral embolism of cardiac source in rheumatic valvular heart disease (RVHD). Platelet studies included platelet aggregation induced by ADP and ristocetin, spontane...

Platelet function tests: a comparative review

In physiological hemostasis a prompt recruitment of platelets on the vessel damage prevents the bleeding by the rapid formation of a platelet plug. Qualitative and/or quantitative platelet defects promote bleeding, whereas the high residual reactivity of platelets in patients on antiplatelet therapies moves forward thromboembolic complications. The biochemical mechanisms of the different phases...